Regenerative skincare has emerged as a leading beauty category. However, some beauty enthusiasts believe regenerative skincare is not necessarily new to the industry, but is a different lens to redefine how industry experts approach healthy and resilient skin through treatments and topical products.
While some skincare trends may be fleeting for a season or two, regenerative skincare encompasses ways to support the skin’s natural renewal process for the long haul. This can be in-clinic treatments or skincare products that stimulate collagen production, encourage cellular turnover, strengthen the skin barrier, boost hydration, and optimise overall skin health over time.
There are two standout skincare ingredients that are leading the way in the thriving regenerative beauty space, specifically growth factors and PDRN (Polydeoxyribonucleotide). While PDRN and growth factors deliver rejuvenating skin benefits, these ingredients work in different ways. So, what are the benefits of growth factors, including dual growth factors, and PDRN, and which ingredient is best for your skin type and concerns?

What is 2GF?
‘GF’ stands for growth factors, therefore 2GF means Dual Growth Factors. Dual Growth Factors are typically made up of two proteins, including EGF (Epidermal Growth Factor) and FGF (Fibroblast Growth Factor). EGF functions to renew skin cells, repair and support the skin barrier, as well as improve surface texture, while FGF works on a deeper level to stimulate collagen and elastin production for a plump and youthful complexion. Together, these Dual Growth Factors support anti-aging concerns as they encourage skin renewal and regeneration.
Traditionally, growth factors are derived from animal ingredients. However, haruharu wonder’s Black Rice 2GF Botanical Wonderful Ampoule uses plant-based growth factors to honour the brand’s vegan ethos. The Dual Growth Factor complex in the Black Rice 2GF Botanical Wonderful Ampoule functions to accelerate cell regeneration, boost collagen production, plump the skin, as well as improve skin texture and repair the dermis.
The latest launch from haruharu wonder also contains fermented black rice, which calms irritated skin, rejuvenates the complexion, and boosts luminosity. The Ampoule is also enriched with hyaluronic acid for a deep boost of hydration, soothing madecassoside, as well as adenosine, which minimizes the appearance of fine lines.
The cocktail of ingredients in this lightweight serum aim to plump, brighten and rejuvenate all skin types. But don’t just take our word for it; clinical studies have found the skin is 22.51% more hydrated, the skin elasticity has improved, and wrinkles reduced after one month of consistent use.

What is PDRN?
PDRN is a popular skincare treatment, which is commonly associated with invasive treatments using salmon DNA, though it is also infused in at-home topical skincare products.
While the formulation, dosage, and delivery system may vary, PDRN aims to support skin renewal as it encourages tissue repair and cell turnover, stimulates collagen production, and boosts luminosity.
Haruharu wonder uses a vegan PDRN alternative in its selection of PDRN products, which has been derived from Damascus rose stem cells. This ingredient is effective yet gentle on the skin.
Out of haruharu wonder’s PDRN skincare saviours, the Rose PDRN Soothing Serum is my personal favourite product to calm, repair, and nourish my skin without any irritation. Alongside the hero vegan PDRN ingredient, the Soothing Serum contains azelaic acid that targets breakouts, calms redness, reduces inflammation and smooths the skin texture. It is also infused with sodium PCA, panthenol and squalane for added hydration.
How to use 2GF and PDRN?
Both haruharu wonder’s Black Rice 2GF Botanical Wonderful Ampoule and Rose PDRN Soothing Serum are super easy to integrate into your daily skincare routine. They can be applied to dry skin immediately after cleansing, or after a toner, such as the Black Rice Hyaluronic Toner or Black Rice Probiotics Barrier Essence.
To use, simply massage a few drops of the Ampoule into the skin, and when it has fully absorbed you can apply the Rose PDRN Soothing Serum. While you can apply both products in the morning and evening, I would recommend the latter for your evening skincare regime to allow it to work its healing magic on the skin overnight.
For extra barrier support and hydration in the daytime, follow with the Black Rice 5 Ceramide Barrier Moisturizing Cream, and the all-important SPF. Alternatively, you can combine your daily moisturiser and sun protection in one with the Moisture Airyfit Daily Sunscreen SPF 50+.
2GF Vs PDRN: Which is best for you?
If you are undecided whether to use the Rose PDRN Soothing Serum or the Black Rice 2GF Botanical Wonderful Ampoule, you must understand your personal skin needs and concerns.
The Black Rice 2GF Botanical Wonderful Ampoule is ideal for those looking for anti-aging treatments, and topical products that aim to improve the skin tone, texture and firmness. The Ampoule is a lightweight, fast absorbing and non-greasy serum, which targets fine lines and wrinkles, plumps the skin and evens the texture. As it is a hydrating serum, it is suitable for those with dry and combination skin, as well as sensitive skin types looking to improve their skin barrier.
The Rose PDRN Soothing Serum is one skincare item my beauty kit would not be complete without because it delivers numerous skin benefits in one gentle and non-greasy formula. For me, it soothed my sore, broken and inflamed skin, calmed aggressive breakouts, improved my uneven skin tone, and left my skin glowing, which are telltales signs my compromised skin barrier was repaired after consistent use. Clinical studies also highlighted customers noticed 88.93% improvement in hydration, improved skin texture, and reduced redness after just one use. So, if you are struggling with sensitive or dry skin, are prone to breakouts, redness, inflammation or have a dull complexion, the Soothing Serum works wonders.
In short, the Black Rice 2GF Botanical Wonderful Ampoule is ideal to improve skin elasticity, offer anti-aging benefits and promote collagen production, while the Rose PDRN Soothing Serum is a reparative, rejuvenating, healing product to soothe stressed skin and make the skin barrier more resilient.
Final thoughts
While you can opt for either haruharu wonder’s Black Rice 2GF Botanical Wonderful Ampoule or the Rose PDRN Soothing Serum, we recommend incorporating both products into your daily skincare routine for an intense treatment that addresses numerous skincare concerns. Combined, this duo will repair and renew your skin without any irritation. The added bonus is that both products are suitable for all skin types, including those with sensitive skin.
2GF Vs PDRN: Which Skin-Regenerative Ingredient Is Best for You?
Regenerative skincare has emerged as a leading beauty category. However, some beauty enthusiasts believe regenerative skincare is not necessarily new to the industry, but is a different lens to redefine how industry experts approach healthy and resilient skin through treatments and topical products.
While some skincare trends may be fleeting for a season or two, regenerative skincare encompasses ways to support the skin’s natural renewal process for the long haul. This can be in-clinic treatments or skincare products that stimulate collagen production, encourage cellular turnover, strengthen the skin barrier, boost hydration, and optimise overall skin health over time.
There are two standout skincare ingredients that are leading the way in the thriving regenerative beauty space, specifically growth factors and PDRN (Polydeoxyribonucleotide). While PDRN and growth factors deliver rejuvenating skin benefits, these ingredients work in different ways. So, what are the benefits of growth factors, including dual growth factors, and PDRN, and which ingredient is best for your skin type and concerns?
What is 2GF?
‘GF’ stands for growth factors, therefore 2GF means Dual Growth Factors. Dual Growth Factors are typically made up of two proteins, including EGF (Epidermal Growth Factor) and FGF (Fibroblast Growth Factor). EGF functions to renew skin cells, repair and support the skin barrier, as well as improve surface texture, while FGF works on a deeper level to stimulate collagen and elastin production for a plump and youthful complexion. Together, these Dual Growth Factors support anti-aging concerns as they encourage skin renewal and regeneration.
Traditionally, growth factors are derived from animal ingredients. However, haruharu wonder’s Black Rice 2GF Botanical Wonderful Ampoule uses plant-based growth factors to honour the brand’s vegan ethos. The Dual Growth Factor complex in the Black Rice 2GF Botanical Wonderful Ampoule functions to accelerate cell regeneration, boost collagen production, plump the skin, as well as improve skin texture and repair the dermis.
The latest launch from haruharu wonder also contains fermented black rice, which calms irritated skin, rejuvenates the complexion, and boosts luminosity. The Ampoule is also enriched with hyaluronic acid for a deep boost of hydration, soothing madecassoside, as well as adenosine, which minimizes the appearance of fine lines.
The cocktail of ingredients in this lightweight serum aim to plump, brighten and rejuvenate all skin types. But don’t just take our word for it; clinical studies have found the skin is 22.51% more hydrated, the skin elasticity has improved, and wrinkles reduced after one month of consistent use.
What is PDRN?
PDRN is a popular skincare treatment, which is commonly associated with invasive treatments using salmon DNA, though it is also infused in at-home topical skincare products.
While the formulation, dosage, and delivery system may vary, PDRN aims to support skin renewal as it encourages tissue repair and cell turnover, stimulates collagen production, and boosts luminosity.
Haruharu wonder uses a vegan PDRN alternative in its selection of PDRN products, which has been derived from Damascus rose stem cells. This ingredient is effective yet gentle on the skin.
Out of haruharu wonder’s PDRN skincare saviours, the Rose PDRN Soothing Serum is my personal favourite product to calm, repair, and nourish my skin without any irritation. Alongside the hero vegan PDRN ingredient, the Soothing Serum contains azelaic acid that targets breakouts, calms redness, reduces inflammation and smooths the skin texture. It is also infused with sodium PCA, panthenol and squalane for added hydration.
How to use 2GF and PDRN?
Both haruharu wonder’s Black Rice 2GF Botanical Wonderful Ampoule and Rose PDRN Soothing Serum are super easy to integrate into your daily skincare routine. They can be applied to dry skin immediately after cleansing, or after a toner, such as the Black Rice Hyaluronic Toner or Black Rice Probiotics Barrier Essence.
To use, simply massage a few drops of the Ampoule into the skin, and when it has fully absorbed you can apply the Rose PDRN Soothing Serum. While you can apply both products in the morning and evening, I would recommend the latter for your evening skincare regime to allow it to work its healing magic on the skin overnight.
For extra barrier support and hydration in the daytime, follow with the Black Rice 5 Ceramide Barrier Moisturizing Cream, and the all-important SPF. Alternatively, you can combine your daily moisturiser and sun protection in one with the Moisture Airyfit Daily Sunscreen SPF 50+.
2GF Vs PDRN: Which is best for you?
If you are undecided whether to use the Rose PDRN Soothing Serum or the Black Rice 2GF Botanical Wonderful Ampoule, you must understand your personal skin needs and concerns.
The Black Rice 2GF Botanical Wonderful Ampoule is ideal for those looking for anti-aging treatments, and topical products that aim to improve the skin tone, texture and firmness. The Ampoule is a lightweight, fast absorbing and non-greasy serum, which targets fine lines and wrinkles, plumps the skin and evens the texture. As it is a hydrating serum, it is suitable for those with dry and combination skin, as well as sensitive skin types looking to improve their skin barrier.
The Rose PDRN Soothing Serum is one skincare item my beauty kit would not be complete without because it delivers numerous skin benefits in one gentle and non-greasy formula. For me, it soothed my sore, broken and inflamed skin, calmed aggressive breakouts, improved my uneven skin tone, and left my skin glowing, which are telltales signs my compromised skin barrier was repaired after consistent use. Clinical studies also highlighted customers noticed 88.93% improvement in hydration, improved skin texture, and reduced redness after just one use. So, if you are struggling with sensitive or dry skin, are prone to breakouts, redness, inflammation or have a dull complexion, the Soothing Serum works wonders.
In short, the Black Rice 2GF Botanical Wonderful Ampoule is ideal to improve skin elasticity, offer anti-aging benefits and promote collagen production, while the Rose PDRN Soothing Serum is a reparative, rejuvenating, healing product to soothe stressed skin and make the skin barrier more resilient.
Final thoughts
While you can opt for either haruharu wonder’s Black Rice 2GF Botanical Wonderful Ampoule or the Rose PDRN Soothing Serum, we recommend incorporating both products into your daily skincare routine for an intense treatment that addresses numerous skincare concerns. Combined, this duo will repair and renew your skin without any irritation. The added bonus is that both products are suitable for all skin types, including those with sensitive skin.